SIRT1 and cancer: No. 5809354, ChemBridge Corp, San Diego, CA, USA), previously shown to downregulate expression of FLIP via HDAC3,6 and 8-mediated histone deacetylation affecting FLIP mRNA in cancer cells in vitro [30,31], functions, specifically in lung fibroblasts, as a SIRT1 inhibitor, destabilizing the FLIP and Fas signaling of apoptosis.