In a study using a different model of stroke (tMCAO for 30 min), PrP0/0 mice had an increased activation of ERK1/2, signal transducer and activator of transcription 1(STAT-1), JNK1/2, and caspase-3 at 3 h after reperfusion, which was neither observed in WT nor in tga20 mice [49]. The gene discussed is MAPK8; the disease is Stroke.