Although PrPC in some pathological conditions can signal through p38 [83,84] that it is upregulated in the penumbra shortly after tMCAO in mice, and together with JNK, plays a role in stroke [73,85], no direct mechanistic link between PrPC and these MAPK has so far been described in the context of cerebral ischemic damage. Here, MAPK8 is linked to Stroke.