As a consequence of reduced proteasomal activity, the Hypoxia-Inducible Factor-1α (HIF-α, which promotes differentiation of neural stem and progenitor cells (NSPCs) [180]) and the pituitary adenylate cyclase-activating polypeptide ((PACAP38) also related to neuroprotection in stroke [181]) were not degraded. The gene discussed is ADCYAP1; the disease is stroke disorder.