However, it is conceivable that the manipulation of PrPC amounts (or its C1 fragment) in EVs improves the delivery of therapeutic agents to recipient cells (e.g., neurons at the penumbra); and as sPrP and N1 have been involved in neurite outgrowth and neuroprotection (as mentioned above), stimulation of the production of these fragments could also have therapeutic potential in ischemic stroke. Here, PRNP is linked to ischemic stroke.