EGF and neoplasm: Since increased vasculature may increase the nutrient and oxygen supply, facilitating the outgrowth of dormant/quiescent cells, and EGF is involved in tumor angiogenesis by acting on vascular endothelial cells in both an indirect and a direct manner [28], we reasoned that EGF produced by SCCs acts as a proangiogenic factor that contributes to the awakening of dormant cells in vivo.