IL6 and Alzheimer disease: In the hypothalamus, no differences were obtained between the different genotypes in Agrp, whereas Il6 mRNA levels were increased in 3xTg-AD males (a ~36% in 3xTg-AD vs WT) (p = 0.026 R2 = 0.47), an effect reversed by the inhibition of the IL-6 trans-signaling (p = 0.007).