Significant differences were also observed for leptin (decreasing a ~79.9% (male) and ~43.2% (female) in 3xTg-AD vs WT) (males p < 0.001 R2 = 0.46; females p = 0.002 R2 = 0.46) and FGF-21 (from ~33.1 to 45.3% in 3xTg-AD vs WT). This evidence concerns the gene LEP and Alzheimer disease.