GFAP and Alzheimer disease: This mild phenotype may have to do with (i) the fact that we used hemizygous mice because of the experimental design (need to cross the AD and GFAP-sgp130Fc strains), which shall decrease significantly Aβ production [28,49,50,51]; (ii) genetic background of the used strains [52]; (iii) differences in the housing conditions or in the used methodology [53].