IL6 and Alzheimer disease: Thus, all of them were decreased (from ~29 to 74% in 3xTg-AD vs WT) significantly in 3xTg-AD male (WATSc p < 0.001 R2 = 0.50; WATGon p = 0.032 R2 = 0.27; BAT p = 0.001 R2 = 0.38; Liver p = 0.002 R2 = 0.31) and female (from ~23 to 56% in 3xTg-AD vs. WT) mice (WATSc p < 0.001 R2 = 0.69; WATGon p = 0.002 R2 = 0.50; BAT p < 0.001 R2 = 0.64; Liver p = 0.008 R2 = 0.37), and the inhibition of IL-6 trans-signaling further decreased them in all females (WATSc p < 0.005 ; WATGon p = 0.005; BAT p = 0.001).