SIRT1 and idiopathic pulmonary fibrosis: Inhibition of SIRT1 deacetylation activity, by a specific mutation on SIRT1 as with SIRTy/y chimeric mice, was associated with reduced FLIP expression, increased apoptosis cascades, and decreased survival pathways in IPF-lung fibroblasts, with attenuation of experimental fibrosis in mouse lungs.