This is explained by the decreased SIRT1 deacetylation activity concomitant to recently published data demonstrating in the experiments in vitro and in vivo, that miR-34a expression is inversely correlated with FLIP levels in lung myofibroblasts of animals with bleomycin-induced pulmonary fibrosis, and miR-34a-mediated downregulation of FLIP positively affects fibrosis outcome [24]. Here, SIRT1 is linked to pulmonary fibrosis.