Fibrotic-lung myofibroblasts both from humans with IPF (Figure 3A) and BLM-treated mice lungs (Figure 3B) have increased SIRT1 (Figure 3A,B, upper panels) with reduced Ku70 acetylation (Figure 3A,B, lower panels) when compared to their normal counterparts (“IPF vs. NL” or “BLM vs. SAL”). This evidence concerns the gene XRCC6 and idiopathic pulmonary fibrosis.