Ewing sarcoma (ES), the second most common bone cancer in adolescents and young adults (AYA), is caused by a pathognomonic genomic translocation that juxtaposes an N-terminal EWSR1 gene with one of several E26 transformation-specific (ETS) genes (typically FLI1 or ERG) [1]. Here, FLI1 is linked to Ewing sarcoma.