Intriguingly, the French research team led by Asmane et al. reported in 2012 that exclusive nuclear staining of total IGF-1R was a possible biomarker of IGF-1R Ab response among a group of 16 sarcoma patients that included diverse sarcoma subtypes, including osteosarcoma (n = 4), liposarcoma (n = 6), rhabdomyosarcoma (n = 1), synovial sarcoma (n = 1), desmoplastic small round cell sarcoma (n = 1), and three patients with ES [39]. This evidence concerns the gene IGF1R and osteosarcoma.