SVIP and vibrio infectious disease: In 1976, pursuing a possible shared mechanism between cholera and pancreatic cholera syndrome [1,2,3], an abstract described persistent elevated stool vasoactive intestinal polypeptide (sVIP) levels in Bangladeshi cholera patients and in U.S. volunteers contracting cholera or enterotoxigenic Escherichia coli diarrhea in vaccine development studies [4].