Moreover, CBS overexpression in the substantia nigra or striatum ameliorated motor deficits and dopaminergic neuron loss in MPTP (1-methy-4-phenyl-1,2,3,6-tetrahydropyridine)-treated mice or 6-hydroxydopamine (6-OHDA)-lesioned PD rats [103,104]. Here, CBS is linked to Parkinson disease.