CD274 and neoplasm: In one study, assessment of PD-L1 expression using a combined positive score (CPS), i.e., the determination of PD-L1 expression in tumor and immune cells, showed that such expression was significantly associated with response rate, with ORR of 4.1% for CPS < 1.5, and ORR of 10% for CPS ≥ 10 [204].