Of interest, a mAb specific to carcinoembryonic Ag (CEA), that leads to tumor opsonization and elimination by antibody dependent cell-mediated cytotoxicity (ADCC) or complement-mediated cytotoxicity (CDC) [210], could actually have an innate ICB activity through the blockade of CEA’s interaction with carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), the latter of which enacts an inhibitory activity in NK cells [211]. The gene discussed is CEACAM1; the disease is neoplasm.