BCL2 and esophageal cancer: Similarly crocin, a naturally derived compound obtained from the stigma of Crocus sativus (saffron) and crocetin, the major constituent of saffron, have been reported to enhance the chemosensitivity of CDDP in lung and esophagus cancer cells, respectively, by upregulation of p53/p21waf1 and Bax levels with a concomitant decrease of Bcl-2 [36,37].