CCR5 and metastatic malignant neoplasm in the lymph nodes: Gonzalez et al. [49] evaluated the immunohistochemical expression of chemokine receptors in a retrospective cohort of 76 cases of head and neck squamous cell carcinoma, and found a positive correlation between CCR5 expression and lymph node metastasis, advanced clinical stage, poor tumor differentiation, recurrence, and shortened disease-free survival [49].