In cholangiocarcinoma (bile duct cancer), the presence of TNF-α and IFN-γ, due to early inflammatory, stimulates MSCs to secrete TNF-α, CCL5 and IL-6, to express indoleamine 2,3-dioxygenase, to activate NF-κB, and to increase their migratory abilities [123]. The gene discussed is TNF; the disease is cholangiocarcinoma.