Histon deacetylation (HDAC) has been reported to reduce expression of MHC-I and key components of the APM, such as the proteasome subunits LMP-2 and LMP-7, and TAP in multiple types of cancer, including neuroblastoma, glioma, Merkel cell carcinoma, cervical cancer, and melanoma [187,210,211,212]. The gene discussed is HDAC9; the disease is melanoma.