TBK1 and Patent ductus arteriosus: In SK-Mel-28 cells and murine tumors, we found an increase in p62 after the administration of amlexanox, which is consistent with elevated levels of p62 in TBK1-deficient mice and the inhibition of autophagy by a combined Janus Kinase (JAK)/TBK1/IKKε inhibitor in pancreatic ductal adenocarcinoma (PDA) [47,48].