Since previous studies indicated that these proteins also constitute major IKKε/TBK1substrates [4,23,51], we wanted to clarify if the corresponding signaling pathways might contribute to melanoma cell proliferation, migration and invasion and therefore investigated the impact of amlexanox on the activation status of NF-кB p65, Akt1 and the MAP kinases ERK (p42/44) and p38 MAPK. This evidence concerns the gene AKT1 and melanoma.