It was shown that 20 dynes/cm2 shear force significantly induces SCD-1 protein (Figure 1A and Supplementary Figure S1) and mRNA (Figure 1B) expressions in human MG63 osteosarcoma cells after 8 and 24 h of treatment, which is approximately 3~4 times that of the untreated controls. This evidence concerns the gene SCD and osteosarcoma.