M2 macrophages, in turn, secrete high levels of cytokines, chemokines, enzymes, and growth factors, such as VEGF, PDGF, TGF-β, FGF, uPA, and several matrix metalloproteinases, most of them encoded by genes that are transcriptional targets of NF-κB, NFAT, and STAT3 signaling pathways [9], thereby increasing inflammation as well as promoting tumor progression, immunosuppression, angiogenesis, migration, metastasis, and treatment resistance [5,7]. The gene discussed is VEGFA; the disease is neoplasm.