During hyperglycemia-mediated oxidative stress, high levels of ROS lead to endothelial dysfunctions by damaging DNA, proteins, lipids, and by deregulating NO production and the redox sensitive transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of genes encoding redox enzymes [10,17,18,19,20,21]. Here, NFE2L2 is linked to endothelial dysfunction.