PRKN and Parkinson disease: In addition to genes causing autosomal dominant forms of PD, other genes, including the parkin RBR E3 ubiquitin protein ligase (PRKN, PARK2), parkinsonism associated deglycase (DJ-1, PARK7), PTEN induced kinase 1 (PINK1), and F-box protein 7 gene (FBXO7), are responsible for juvenile-onset autosomal recessive PD forms [28,32].