CD274 and neoplasm: Beyond the currently performed molecular analyses (e.g., mutational load, driver mutations, gene expression of immunosuppressive factors) and immune profiling (PD-L1 expression, CD8+ T-cells, T-cell clonality), the so-called “absence of inhibitory metabolism” (i.e., plasma lactate dehydrogenase levels, glucose utilization) is beginning to be incorporated into immunogram models to better understand the interaction between the tumor and immune cells in the TME [170].