We recently documented how the dietary polyphenol resveratrol significantly reduces the immune evasion activity of PD-L1 by operating as a direct inhibitor of the glyco-PD-L1-processing enzymes (α-glucosidase/α-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the ER retention of a mannose-rich, abnormally glycosylated form of PD-L1 and, consequently, increasing the susceptibility of cancer cells to T-cell-mediated cell death [143]. Here, CD274 is linked to cancer.