CD274 and neoplasm: Such metabolo-epigenetic regulatory mechanisms might be of relevance to molecularly understand and clinically capture the heterogeneous and dynamic nature of PD-L1 expression within tumors and between different tumor sites, which largely limits the clinical value of measuring PD-L1 expression status as a companion diagnostic for the benefit-risk assessment of PD-1/PD-L1 inhibitors [139,140].