PF4 and atherosclerosis: In addition, PF4 promotes reactive oxygen species (ROS) generation in vascular disorders [31], such as atherosclerosis or ischemia/reperfusion injury, and monocyte recruitment to the endothelium by means of its binding with RANTES (regulated on activation, normal T cell expressed and secreted), which is stored in high amounts in platelet α-granules and plays an active role in the atherosclerotic disease process [32].