BICC1 and autosomal dominant polycystic kidney disease: In 2019, Millet-Boureima et al. tested the effect of Smac (second mitochondria-derived activator of caspases) mimics, of which one was previously shown to suppress the pathological phenotype in an ADPKD rat model, in the BicC mutant fly model of ADPKD and found important cyst reduction upon Smac treatment [134].