PKD1 and Kidney Cyst: Cao et al. identified histone deacetylase (HDAC) inhibitors as candidates for PKD treatment using zebrafish Pkd2/hi4166 (which does not develop a cystic phenotype but instead a dorsal body curvature) and ift172/hi2211 mutants (developing ventral body curvature and kidney cyst formation), zebrafish Pkd2 morphants and a murine kidney specific Pkd1 knock-out model [140].