For ADPKD research, the high-throughput platforms using 3D cysts [66] or kidney organoids derived from PKD knock-out hPS cells [36], as well as the automated imaging pipeline using zebrafish larvae [143] in combination with Pkd1a/b or Pkd2 morpholino oligos could be particularly useful to detect promising candidates while limiting false positives. The gene discussed is PKD2; the disease is autosomal dominant polycystic kidney disease.