Also, in 2014, Sussman et al. identified two zebrafish homologues of the phosphodiesterase 1A (PDE1A), an enzyme interesting in the context of ADPKD because of its capacity to hydrolyze cAMP and as the unique PDE isoform regulated by Ca2+ [129]. Here, ALDH7A1 is linked to autosomal dominant polycystic kidney disease.