PKD2 and cyst: In 2016, Wu et al. employed a multimodal approach, using a 3D cyst assay with human renal epithelial cells (immortalized and normal), zebrafish Pkd2 morphants and the Han:SPRD rodent model, which led to the identification of a beneficial effect of resveratrol on PKD progression, as well as of NF-κb as a potential therapeutic target [141].