Atherosclerotic apolipoprotein E knock-out (ApoE−/−) and low-density lipoprotein receptor knock-out (LDLR−/−) mice are popular models to study the development of arterial intimal calcification [22], with both micro- and macro-calcifications frequently detected in severe atheromatous plaques [23,24], as is the case in humans. The gene discussed is APOE; the disease is calcification.