Of note, mutations in the interleukin 6 (IL6) signal transducer gp130, which blocked SHP2–Ras–ERK signaling (gp130757F mice), showed reduced Tff1 levels and a phenotype (antropyloric adenomas, but no carcinomas) highly similar to Tff1KO mice [51,52]. Here, IL6 is linked to carcinoma.