The good news is that inhibitors of HIV protease or reverse transcriptase and CXCR4 antagonists, which have been used for many years to counter HIV infection, effectively inhibit MMP-9 expression and tumor cell dissemination [20,157,158,159,160,161,169,170,171,172,173,174,216,227]. This evidence concerns the gene CXCR4 and HIV infectious disease.