HSPA5 and infection: Interestingly, Zilucoplan, Obinepitide and Corticorelin ovine triflutate were found to have lower free energy of binding (higher affinity) to GRP78 SBD than SARS-CoV-2 (C480–C488), which suggests that these compounds may compete with the virus spike for binding, thus preventing the internalization of SARS-CoV-2 and consequent infection.