It should be stressed that the exact mechanisms of melatonin underlying the suppression of these oncogenes are still unclear, however, some reports linked it to the direct interaction of with Bridging Integrator 1 (BIN1) that considers as HCC suppressant gene with c-Myc, leading to downregulation of c-Myc associated with HCC [121]. Here, BIN1 is linked to hepatocellular carcinoma.