Furthermore, for colorectal cancer, it was shown that the prognostic relevance of TP53 may be mediated by a subtype specific effect on the tumor immune cell infiltration with TP53 mutations identifying a non-immunogenic subgroup [34], and one can speculate that this may interfere with the immunogenic properties of the MSI-H phenotype in a particular subset of the patients. Here, TP53 is linked to colorectal cancer.