WNK2 and cardiac hypertrophy: In particular, the administration of an adeno-associated virus expressing miR-1 in rats with cardiac hypertrophy induces the regression of hypertrophy, compared to a control group; several weeks after treatment, the reduction of myocardial fibrosis, an improvement in calcium handling, inhibition of apoptosis, and inactivation of the mitogen-activated protein kinase signaling pathways are observed [292].