KDM4A and cardiac hypertrophy: Jumonji domain-containing protein 2A (JMJD2A) catalyzes the demethylation of trimethylated histone H3K9 (H3K9me3) and H3K36 (H3K36me3) and mediates cardiac hypertrophy through the regulation of its target four and a half LIM domains protein 1 (FHL1) [129].