First, we analyzed the association between pretreatment ATX and M2BPGi levels and post-SVR HCC development using data from Cohort B. The pretreatment ATX levels in patients with post-SVR HCC were higher than those in patients without post-SVR HCC (median values: males, 1.56 mg/L vs. 1.14 mg/L; females, 2.37 mg/L vs. 1.67 mg/L; Figure 2A,B). Here, ENPP2 is linked to hepatocellular carcinoma.