In fact, it has been widely demonstrated that miRNAs are able to regulate different key cytokines expressed during sepsis and significantly mediate their expression as TNF-α [88,89,90], IL-6 [91,92], NFκB [93,94,95], IL-10 [87], IL-18 [96,97], IL-27 [98,99], and other pro-inflammatory and anti-inflammatory cytokines with differential expressions in sepsis. This evidence concerns the gene IL18 and Sepsis.