DMPK and myotonic dystrophy type 1: Drosophila models exist for multisystemic disorders such as Myotonic Dystrophy Type 1 (DM1) that is caused by CTG expansions in the Dystrophia Myotonica Protein Kinase (DMPK) gene leading to the sequestration of RNA binding proteins such as MBNL1 in nuclear foci [295,296].