When co-examined with other genes, impact of TNM stage on TJP1 lost significance as the association occurred to be mediated by CDKN1A and HIF1A. The TJP1 association with tumor extension (T) lost significance as it was mediated by BCL2 and ODC1 and the TJP1 association with lymph node metastasis (N) lost significance as it was mediated by HIF1A. Here, HIF1A is linked to metastatic malignant neoplasm in the lymph nodes.