Using receiver operating characteristic (ROC) curve, adding Gal-3 expression to the tumor size (tumor size minuses Gal-3 expression level) showed a larger area under the curve (AUC) than tumor size alone in both predicting events of metastasis (AUC = 0.747 vs. 0.681, Figure 4A) and recurrence (AUC = 0.813 vs. 0.766, Figure 4B). The gene discussed is LGALS3; the disease is neoplasm.