AKT1 and Familial prostate cancer: A number of genetic alterations in genes that encode AKT regulators have been linked to prostate cancer, including kinases (e.g., PDK1), binding proteins (e.g., FKBP5), and phosphatases (e.g., PHLPP1, PHLPP2, and PP2A) [42,43,44,45,46].