A number of genetic alterations in genes that encode AKT regulators have been linked to prostate cancer, including kinases (e.g., PDK1), binding proteins (e.g., FKBP5), and phosphatases (e.g., PHLPP1, PHLPP2, and PP2A) [42,43,44,45,46]. This evidence concerns the gene PTPA and Familial prostate cancer.