PIK3CA and Familial prostate cancer: Our recent work identified that PIK3CA genetic alterations significantly correlate with poor prostate cancer prognosis, and that Pik3ca oncogenic mutation at a clinically relevant hotspot (H1047R) in mouse prostate epithelium can cause locally invasive prostate adenocarcinoma, demonstrating Pik3ca activation is a genetic driver of prostate cancer in vivo [13].