PIK3CA and plasma cell myeloma: DEPTOR has also been shown to exert mTORC1/2-independent functions in the nucleus as a transcriptional regulator in multiple myeloma cells [189] and is a transcriptional target of WNT/β-catenin/MYC signaling in colorectal cancer cells [188], adding further complexity to PI3K-AKT-mTOR and WNT pathway crosstalk.