LKB1 (encoded by serine/threonine kinase 11, STK11) is a multifaceted enzyme that plays a tumor suppressive role by phosphorylating multiple substrates (e.g., AMPK and PTEN) to regulate crucial cellular processes including cell metabolism, polarity, differentiation, and proliferation [212,213] (Figure 1). Here, PRKAB1 is linked to neoplasm.