Several molecular mechanisms that permit cross-regulation of the PI3K-AKT-mTOR and WNT signaling cascades have emerged in the literature, which could influence prostate cancer growth and resistance to anti-androgens and/or PI3K-AKT-mTOR pathway inhibitors [320,322,323,334,335] (Figure 4). This evidence concerns the gene PIK3CD and Familial prostate cancer.