RRAGD and Familial prostate cancer: In prostate cancer, genetic alterations in RRAGA and RRAGC genes that encode RAGA and RAGC respectively are uncommon, however RRAGB (encoding RAGB) is amplified in up to 7.7% of cases and RRAGD (encoding RAGD) deep deletion occurs in 6.5–14.4% of cases (Tables S1–S3).