Preliminary data from a WNT974 phase 1 clinical trial (NCT01351103) for a small range of human malignancies (excluding prostate cancer) report a manageable safety profile and suppression of canonical WNT/β-catenin target gene AXIN2 [320], and recent preclinical studies have indicated that WNT974 treatment is efficacious against prostate cancer [331,365]. Here, AXIN2 is linked to Familial prostate cancer.