AKT is activated by multiple kinases, including PDK1 and mTORC2 that phosphorylate AKT at residues Thr308 and Ser473 respectively, triggering a wave of phosphorylation through multiple downstream targets that stimulate cell survival, proliferation, metabolism and differentiation to promote tumor growth [19,20,32,123,124]. The gene discussed is AKT1; the disease is neoplasm.