Although the role of PIK3C2B amplification in prostate cancer is not clear, a recent study identified that PI3KC2β is highly expressed in PTEN-negative PC3 and LNCaP prostate cell lines compared to PTEN-positive DU145 prostate cancer cells (PTEN+/−), and PNT2 immortalized “normal” prostate epithelial cells (PTEN+/+) [81]. This evidence concerns the gene PIK3C2B and Familial prostate cancer.