In conjunction with genomic and transcriptomic data, establishing the frequency and impact of post-transcriptional modifications and epigenetic events within core PI3K-AKT-mTOR pathway components during prostate tumorigenesis and disease progression/recurrence is also crucial, as these components are regulated at multiple levels and genomic/transcriptomic data do not consistently equate with protein activity. This evidence concerns the gene AKT1 and male reproductive organ cancer.