Furthermore, a recent study has shown that LKB1 protein levels are reduced in immortalized prostate cancer cell lines relative to normal prostate epithelial cells, and siRNA-mediated STK11 knockdown correlated with elevated hedgehog signaling and increased proliferation and invasion of prostate cancer cells in vitro, however PI3K-AKT-mTOR signaling was not assessed [216]. Here, PIK3CA is linked to Familial prostate cancer.