In humans, mutations in ZC4H2, a zinc-finger nuclear factor, have been reported to cause various clinical phenotypes, including arthrogryposis multiplex congenita, intellectual disability, epilepsy, spasticity, hypotonia, etc., which are now referred to as ZC4H2-associated rare disorders (ZARD) [4,5,6,7,8,9]. The gene discussed is ZC4H2; the disease is Wieacker-Wolff syndrome (spectrum).