Either a dopamine agonist (e.g., pramipexole) or an NLRP3-inhibitor (e.g., MCC950) suppresses the sepsis-mediated lethality in pink1-/- and park2-/- mice, suggesting that PINK1-PARK2-mediated neuroimmunology circuits are involved in the protection against septic shock [167]. The gene discussed is PRKN; the disease is Sepsis.