As it becomes more and more evident that myeloid disease is frequently associated with a block in osteogenic differentiation, and following the observation from mouse models that myeloid neoplasms frequently go together with a dysfunctional bone phenotype (an overview of bone phenotypes in a selection mouse models is shown in Table 2), it is tempting to speculate that similar bone phenotypes can also arise from an increase of monocyte-derived (CD45+) bone cells as shown for RARγ−/− mice [32,33]. Here, PTPRC is linked to myeloid neoplasm.