In a mouse model of inducible BCR-ABL chronic myeloid leukemia (CML), leukemic cells stimulated MSC proliferation by a combination of soluble mediators (CCL3, TPO) and direct cell contact resulting in an overshooting production of early osteolineage cells [51]. The gene discussed is TPO; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.