APP and Alzheimer disease: Quantitative analysis of Aβ plaque load on serial brain slices covering the hippocampus and cortex showed that compared with the AD control groups, Y-5A15-treated mice showed remarkable reduction in the levels of 4G8+ and Thio-S+ plaque by 53% and 60%, respectively (p < 0.01) (Figure 4b,c), indicating that Y-5A15 vaccination conspicuously alleviated the Aβ plaque load in the brain of APP/PS1 mice.