We here designed and prepared a Saccharomyces cerevisiae-based AD vaccine, Y-5A15, and provided strong evidences that Y-5A15 yeast vaccine could serve as effective antigen carrier and adjuvant to enhance the immunogenicity of Aβ1-15, and induced rapid antibody production, exerting favorable effects on cognition and neuropathology in the APP/PS1 mice. This evidence concerns the gene APP and Alzheimer disease.