CERS5 and digestive system neoplasm: CerS5-ko mice showed a significantly reduced colon length and larger colon tumors than CerS5-wt mice (Figure 2D and Figure S1), whereas neither colon length nor tumor volume significantly differed between AOM/DSS-treated CerS5wt/VilCre or CerS5fl/fl/VilCre mice (Figure 2D).