As shown in Figure 2, as patients transited from normouricemia to hyperuricemia, the methylation of PGGT1B (Figure 2A), INSIG1 (Figure 2B), ANGPTL2 (Figure 2C), JNK1 (Figure 2D), UBAP1 (Figure 2E), RECK (Figure 2F), NPC2 (Figure 2G), RAPTOR (Figure 2H), and CNTN5 (Figure 2I) remained the same. Here, INSIG1 is linked to hyperuricemia.