INSIG1 and gout: The seven aberrant DNA methylation sites were mapped to seven genes (PGGT1B, INSIG1, ANGPTL2, JNK1, UBAP1, RAPTOR, and CNTN5) that have not been elucidated in the field of gout except CNTN5. PGGT1B suppresses IL-1β release in macrophages [10].