Moreover, measuring transcription factors identified in this study (Figure S17) and chromatin immunoprecipitation (ChIP) for these transcription factors would provide more clues about the mechanistic link between PGGT1B, INSIG1, ANGPTL2, JNK1, UBAP1, RAPTOR, and CNTN5 methylation and gout. This evidence concerns the gene MAPK8 and gout.