NLRP3 and infectious disease: However, while NLRP3 inflammasome has a central regulatory role in IL-1β production in myeloid cells, and the importance of NLRP3 inflammasome-mediated inflammatory responses has been shown in many infectious diseases [33], the possible effects of ATRA on the NLRP3 inflammasome-mediated IL-1β production and the related regulatory mechanisms are yet to be characterized.