TP53 and B-cell chronic lymphocytic leukemia: In detail, in 2015 Blume et al. reported that the induction of NEAT1 in chronic lymphocytic leukemia (CLL) primary cells could play a role in the DNA damage pathway [4], demonstrating that, after DNA damage, NEAT1 is induced in the presence of functional p53 but not in CLL carrying p53 mutation, and that its induction is closely related to cell death upon DNA damage [4].