The inhibitory activity of ROS on NK cells recruitment was observed in melanoma and sarcoma mouse models [70], furthermore myeloid NADPH oxidase 2 (NOX2)-deficient mice diminished melanoma metastasis and increased Interferon gamma (IFN-γ) generation in NK cells, suggesting that myeloid-derived ROS hamper NK cells control of cancer malignancy [80]. This evidence concerns the gene CYBB and cancer.