On the other hand, ROS could induce the expression of the costimulatory molecule CD80 via the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) pathways, that activated Signal transducer and activator of transcription 3 (STAT3) transcription factor in colon cancer epithelial cells in vitro [62]. This evidence concerns the gene STAT3 and malignant colon neoplasm.