PSEN2 and Alzheimer disease: For example, mutations in presenilin 1 and presenilin 2 genes (PSEN-1 and PSEN-2), which encode for the PSEN-1 and PSEN-2 core catalytic subunits of the γ-secretase complex, facilitate early onset AD, possibly through apoptosis triggered by the collapse of the nucleus due to lamina disruption [110].