The treatment options for patients with RCC have been expanding in the last few years [9] after the advent of immunotherapeutic agents targeting programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis as a single-agent (Table 1) or combined with anti-CTLA-4 monoclonal antibodies (MoAbs) [10]. The gene discussed is CD274; the disease is renal cell carcinoma.