GPT and Hypertension: The most commonly reported G3 or G4 treatment-related AEs were hypertension, diarrhea, increased alanine aminotransferase level, and palmar-plantar erythrodysesthesia in the combination arm, and hypertension, palmar-plantar erythrodysesthesia, and hematological toxicity in the sunitinib arm with three and one treatment-related deaths, respectively [29].