ScRNA-Seq analyses in human PAH patients have uncovered the upregulation of angiogenesis-associated genes in ECs such as endoglin (ENG), NOTCH1 and KDR, together with genes involved in SMC migration and proliferation such as PDGFB and FGFR1, as well as vasoconstrictor endothelin 1 (EDN1) [74]. This evidence concerns the gene ENG and pulmonary arterial hypertension.