SFRP2 and neoplasm: Additionally, the role of SFRP2 in OSCC has been investigated by using in vivo and in vitro models, observing that the methylation of the SFRP2 promoter occurred more frequently in the tumor region than in the nontumor adjacent tissue and that the mRNA encoding for SFRP2 was significantly inhibited in OSCC biopsies [126].