CDH1 and neoplasm: On the one hand, the endocytosis of cell adhesion molecules, such as E-cadherin, contribute to the epithelial-to-mesenchymal transition during tumor progression, whereas endocytic trafficking of cell-extracellular adhesion molecules, specifically integrins, along with the turnover of integrin-based focal adhesions, represent key events to sustain tumor cell migration, invasion and metastasis [137].