At the same time, recent studies have demonstrated that, while increased Lp(a) levels are associated with enhanced atherogenesis, proinflammatory and prothrombotic states [16], a greater risk of cardiovascular events, and poorer prognosis [2,15,17,18], the decreased serum concentrations of Lp(a) are related to the insulin resistance state [19]. This evidence concerns the gene LPA and Insulin resistance.