Comparisons of the regression models in KLK6/HPN between stage III and IV (AUC = 0.727) and HPN/ALDH1A1 chemotherapy versus chemotherapy-naïve CRC patients (AUC = 0.748) did not reveal any significance, although the latter showed the highest specificity of 98.00%. The gene discussed is ALDH1A1; the disease is colorectal carcinoma.