CHI3L1 and colorectal carcinoma: Although several studies were identifying novel serum biomarkers, involving insulin-like growth factor-binding protein 2 (IGFBP-2) [76], heat shock protein 60 (HSP60), and chitinase-3-like protein 1 (CHI3L1) [77], to be strongly correlated with metastasis of CRC, their poor selectivity and sensitivity have rendered the tests unsuccessful due to the high rates of false positives and false negatives.