Cardioprotective action (especially anti-atherosclerosis properties) of 20(S)-protopanaxadiol saponins was also observed in ApoE deficient mice [31] In our present experiments, saponin fraction isolated from sea buckthorn leaves (especially at the highest used concentrations: 10 and 50 μg/mL) showed anti-oxidative against harmful to human plasma protein and lipid oxidation induced by H2O2/Fe. The gene discussed is APOE; the disease is atherosclerosis.