However, when comparing MCI vs. AD, ASC had an AUC of 0.7157, sAPPα 0.6351, sAPPβ 0.5247 and NfL had an AUC of 0.5569, suggesting that, when differentiating MCI vs. AD, ASC is a more reliable serum biomarker. Here, NEFL is linked to Alzheimer disease.